• The canonical binding sites to which

  2025-01-10

  

  The canonical Streptavidin-fluorescein isothiocyanate to which α2, α3, or α5 contribute are highly similar. Therefore, differences in ligand affinity will not be large even if a ligand makes optimal use of the small differences in the pockets. As a possible alternative approach to achieve separatio

• Inflammations lead to the perturbation

  2025-01-10

  

  Inflammations lead to the perturbation of aromatase enzyme [112], which normally is responsible for a broad array of critical functions. Chemotherapy targets this enzyme, so this treatment option is never side-effect-free and not fully-effective. Therefore, the mankind should be careful so as not to

• Once apoptosis has been initiated the HMGA proteins themselv

  2025-01-10

  

  Once apoptosis has been initiated the HMGA proteins themselves undergo marked changes in both the types and extent of their post-translational modifications (PTMs; review in [149,175]), some of which are likely correlated with alterations in chromatin structure. For example, the early stages of apop

• br Telmisartan Telmisartan is one of

  2025-01-10

  

  Telmisartan Telmisartan is one of the widely used antihypertensive agents, which has demonstrated favorable safety and tolerability profiles, both alone and in combination therapies. It has a number of pharmacological properties that distinguish it from other ARBs—the longest plasma half-life, hi

• In addition AMPK reduces protein synthesis and stimulates ap

  2025-01-10

  

  In addition, AMPK reduces protein synthesis and stimulates apoptotic and autophagic pathways through the inhibition of the mechanistic target of rapamycin (mTOR), which regulates cellular metabolic homeostasis, insulin secretion, insulin resistance, autophagy and apoptosis (Maiese, 2016). mTOR is th

• br Author contributions br Financial disclosures br Acknowle

  2025-01-10

  

  Author contributions Financial disclosures Acknowledgements We thank Ms. Eva So for the editorial assistance. This work was supported by grants from the National Natural Science Foundation of China (No. 81622015, 81571042 and 81501143) and the National Basic Research Program of China (No. 2

• br The lipoxygenase pathway in diseases of the nervous

  2025-01-10

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic mCherry mRNA translation efficiency and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outli

• All desired compounds with a carboxylic acid substituent

  2025-01-10

  

  All desired compounds with a carboxylic Trifluridine ophthalmic solution substituent at N1 position of the quinoxalinone scaffold and a variety of aromatic substituents at C3 position were obtained by the syntheses starting from methoxy-substituted 3-chloro-quinoxalin-2(1)-ones () prepared as previ

• 71 8 It is also possible that adrenoceptor

  2025-01-10

  

  It is also possible that α2-adrenoceptor activation may inhibit glutamate accumulation by upregulating the glutamate-buffering activity of Müller 71 8 through EAAT1 or adjusting EAAT2 in bipolar cells, as well as the NMDA receptor. Therefore, we investigated whether topical administration of brimon

• Mt a known to be upregulated by

  2025-01-10

  

  Mt2a, known to be upregulated by ozone (Inoue et al., 2008), was also increased in vehicle-pretreated rats exposed to ozone, however, this effect was markedly reduced by both PROP and MIFE, suggesting that the neuroendocrine response is linked to ozone-induced acute phase protein expression. In huma

• In conclusion this study detected the expression of adiponec

  2025-01-10

  

  In conclusion, this study detected the expression of adiponectin and its receptors, AdipoR1 and AdipoR2, in goat ovarian follicles. In addition, adiponectin was shown to enhance the progression of goat oocyte nuclear maturation in vitro. The present findings provide evidence for paracrine/autocrine

• APPL was the first adaptor protein identified

  2025-01-10

  

  APPL1 was the first adaptor protein identified that interacts directly with adiponectin receptors [18]. A two-hybrid study by Dong and colleagues revealed that the C-terminal extracellular domain of AdipoR1 interacts with adiponectin, whereas the N-terminal cytoplasmic domain of AdipoR1 interacts wi

• Subsequently Palvimaki et al corroborated Ni

  2025-01-09

  

  Subsequently, Palvimaki et al. (1999) corroborated Ni and Miledi's study by demonstrating that treatment with fluoxetine leads to 43% occupancy of the 5-HT2C receptors. Moreover, the affinity of fluoxetine for 5HT2C receptors (Ki 65 nM) is close to its affinity for 5-HT transporters (Ki 33 nM) (Ni a

• Consistent with the observation that mutations in the

  2025-01-09

  

  Consistent with the observation that mutations in the redox-partner binding site of P450c17 that reverse charge from basic to acidic (R347H, R358Q) cause 17,20-lyase deficiency (Geller et al, 1997, Geller et al, 1999), at least one POR mutation that changes a residue in the FMN domain from neutral t

• Acl converts cytosolic citrate CoA and ATP into acetyl

  2025-01-09

  

  Acl converts cytosolic citrate, CoA and ATP into acetyl-CoA, ADP+Pi and oxaloacetate (Fig. 1). This cytosolic enzyme is present in few Prokaryotes and in all Eukaryotes, but not in non-oleaginous yeasts [14]. Thus, this enzyme was presumed to be essential for FA synthesis [1], [13], [15]. In most mi

14443 records 31/963 page Previous Next First page 上5页 3132333435 下5页 Last page