• GSTP catalyzed reduction of Prdx enhances its peroxidase act

  2022-09-08

  

  GSTP1-1 catalyzed reduction of Prdx6 enhances its peroxidase activity. Using standard NADPH/GR/GSH-coupled assays we used cell lysates from the transiently transfected Methoxyresorufin to measure the influence of GSTP1 allelic variation on peroxidase activity. Specificity for detection of Prdx6 acti

• In plants NO production is one of the early responses

  2022-09-08

  

  In plants, NO production is one of the early responses to stress (Tossi, Lamattina, & Cassia, 2009). Usually, NO signal transduction requires the involvement of downstream signaling compounds. We further investigated the effects of cGMP on GSK-3 expression. The data showed that LY83583 (a cGMP inhib

• Historically pharmacological investigations have been carrie

  2022-09-08

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• While published data around the functional significance of

  2022-09-08

  

  While published data around the functional significance of GPR84 are quite sparse, details of signaling pathways initiated by the receptor are even more limited, including in recombinant systems. In recombinant cells, GPR84 activation reportedly leads to Gi pathway activation, resulting in pertussis

• However although lactic acid suppresses the activation of

  2022-09-08

  

  However, although lactic MK1775 suppresses the activation of effector , rendering them unable to buffer intracellular acidity [32], other T cell subpopulations such as regulatory T cells (Tregs) exhibit metabolic adaptations in low-glucose, high-lactate environments. In particular, Treg transcripti

• br Lysophosphatidylinositol LPI LPI is a subspecies of lysop

  2022-09-08

  

  Lysophosphatidylinositol (LPI) LPI is a subspecies of lysophospholipid consisting of inositol as its head group, one glycerol molecule and one acyl chain (Piñeiro and Falasca, 2012). The biosynthesis of this lipid starts from Phosphatidylinositol (PI) and is catalysed by the enzymes phospholipase

• br TGR agonists current developments and future landscape Th

  2022-09-08

  

  TGR5 agonists: current developments and future landscape The amphipathic nature of bile acids is crucial in aiding the digestion and Ro3306 mg of vitamins and fats. With the emerging roles of bile acids in the regulation of energy and glucose homeostasis through TGR5, the pharmaceutical industry

• GT cells were treated in

  2022-09-08

  

  GT1-7 GW788388 were treated in two ways; specifically, they were either dosed or transfected with VP, reflecting the extracellular and intracellular actions of VP, respectively. A dose of 200 pg/ml VP in culture supernatants was effective in stimulating GnRH in the supernatant and cell extracts; th

• could br Transporter based brain targeting nano

  2022-09-07

  

  Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the could from harmful substances. Since only selected, neutral, lipophilic small molecule

• Specifically The unique mechanism of EAAT anion channel

  2022-09-07

  

  The unique mechanism of EAAT anion channel gating results in neuronal or glial anion conductances that follow changes in substrate concentrations and thus allow feedback control of glutamate release (Wersinger et al., 2006) or modification of GABAergic postsynaptic currents by glutamatergic signals

• To further implicate the role of EAAT in morphine

  2022-09-07

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 chronic conditions was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-ty

• isoquercitrin receptor The dopamine substrate currents IDA I

  2022-09-07

  

  The dopamine substrate currents (IDA – IControl) were determined at different holding potentials (IV curves) in transfected HT22 cells (Fig. 5A). The plot for HT22 cells transfected with DAT exhibited the typical behavior of dopamine transporter currents (Ingram et al., 2002; Sonders et al., 1997),

• br Experimental methods br Acknowledgments

  2022-09-07

  

  Experimental methods Acknowledgments We thank all members of the Hermanson lab, especially Ana Teixeira, Shirin Ilkhanizadeh and Karolina Wallenborg, for assistance and discussions, Peter Löw for anti-synaptotagmin antibody, and Lars Björklund, Ole Isacson, Christer Höög, Claes Wahlestedt and

• br Material and methods br Results br Discussion Accumulatin

  2022-09-07

  

  Material and methods Results Discussion Accumulating evidence suggests that the hippocampus is sensitive to noise-induced hearing loss and other forms of sensory deprivation, which deprives the hippocampus of sensory information required for its normal operations such as spatial navigation

• br Results br Discussion secretase mediated proteolysis

  2022-09-07

  

  Results Discussion γ-secretase-mediated proteolysis of integral membrane proteins is required for diverse biological processes (Lal and Caplan, 2011). One γ-secretase target of particular interest is Notch, as recent work has shown Notch activity to be increased in obesity and associated metab

14371 records 367/959 page Previous Next First page 上5页 366367368369370 下5页 Last page