• Lean mass is representative of the muscle tissue mass equiva

  2022-07-29

  

  Lean mass is representative of the muscle tissue mass equivalent of all the body parts containing water, excluding fat, bone minerals, and such substances which do not contribute to the NMR signal, such as hair, claws, etc. (ECHO-MRI (Houston, TX) user's manual). It was interesting that in the Bob-C

• Introduction Nicotinic acid niacin NA has been used in

  2022-07-29

  

  Introduction Nicotinic STA-21 (niacin, NA) has been used in the treatment of dislipidemia and cardiovascular disease for almost 60years (Offermanns, 2006). Large clinical studies showed that niacin alone or in combination with LDL-lowering drugs improved cardiovascular outcomes (Canner et al., 1986

• Considering the fact that OCL

  2022-07-29

  

  Considering the fact that OCL induced depletion of T N6-Methyl-dATP in non-stimulated cultures, the only possible explanation of this effect is the elevated mortality of these cells. It was found that OCL at the higher concentration induced the apoptosis of CD4+ and CD8+ T cells. These results stron

• Next we designed substituents of

  2022-07-29

  

  Next, we designed substituents of the 6-position. Edge-to-face aromatic interaction between aromatic ring of ligand and Phe162B needed to be retained because the interaction seems to be important for tight binding. 3′-Position of the 6-phenyl group of directs to a hydrophilic space where W1 exists.

• Hepatic drug metabolizing enzymes and

  2022-07-29

  

  Hepatic drug-metabolizing Rebastinib and transporters expression were regulated by nuclear receptors [19], [20], [21]. The effects of HFD-induced fatty liver on drug metabolizing enzymes in mice were recently studied, and the results provided a systematic evaluation of the changes of nuclear recept

• The existence of EAAT subtypes raises obvious

  2022-07-29

  

  The existence of 5 EAAT subtypes raises obvious questions as to the cellular and anatomical distribution of the various transporters (for review, see Gegelashvili & Schousboe, 1998, Danbolt, 2001). While difference in techniques (i.e., protein vs. mRNA), reagents, and preparations (i.e., in vivo vs.

• Cortisol is a natural glucocorticoid hormone produced by

  2022-07-29

  

  Cortisol is a natural glucocorticoid hormone produced by the adrenal cortex. Its secretion is stimulated by the sympathetic nervous system, and its main function is to mobilize energy to protect the homeostasis of vital biochemical processes during physical and psychological stress [14]. Chronic lev

• br Methods br Results br

  2022-07-29

  

  Methods Results Discussion Significant alterations in the expression of genes related to the glutamatergic system have been shown in several experimental models of epilepsy; however, in most studies focused on acute changes or modifications in expression, these were investigated during the

• angiotensin receptor blockers Fourthly the distribution site

  2022-07-29

  

  Fourthly, the distribution sites after i.c.v. injection of FAM-ghrelin(1–7)-NH2 were explored in mice using the technologies of fluorescence labeling. The green fluorescence of FAM-ghrelin(1–7)-NH2 was strongly distributed in these structures of lateral ventricle, lateral septal nucleus, dorsal part

• By using pharmacological treatment with CBX

  2022-07-29

  

  By using pharmacological treatment with CBX or transgenic animals lacking the two major astroglial Cxs, the Double KO mouse, we demonstrated that the gap-FRAP technique was able to detect the total inhibition of GJC with a reduction of about 39% and 38% compared to control, respectively. The residua

• A group of small molecule with a more promising therapeutic

  2022-07-29

  

  A group of small molecule with a more promising therapeutic mechanism are known as γ-secretase modulators (GSMs), which modulate the cleavage activity of γ-secretase (and likely a host of other substrates) and specifically reduce the levels of the fibrillogenic Aβ42 peptide without altering the ε-si

• Inflammasomes are multimeric protein complexes

  2022-07-29

  

  Inflammasomes are multimeric protein complexes involved in the host defense protecting activity against invading pathogens and in physiological aberrations such as cancer and auto-inflammatory, metabolic, and neurodegenerative diseases. Inflammasomes induce the inflammatory process by triggering the

• A mutation in stearoyl coenzyme

  2022-07-29

  

  A mutation in stearoyl coenzyme A desaturase 1 gene was reported to reduce sebum production and monounsaturated fatty acids (MUFA) synthesis in mice, which was accompanied with impaired clearance of gram-positive bacteria-induced skin infection (Georgel et al., 2005). Interestingly, gram-positive ba

• br Results and discussion The synthesis of core aldehyde

  2022-07-29

  

  Results and discussion The synthesis of core aldehyde building block 2 commenced with known aldehyde 5. The Horner–Wadsworth-Emmons olefination of the latter (using commercially available 6) gave cinnamate ester 7. Facile hydrogenation of the double bond in 7 was achieved over Raney nickel withou

• br Experimental section br Acknowledgements This

  2022-07-29

  

  Experimental section Acknowledgements This study was supported by grants from the National Natural Science Foundation of China (Grants 81673299 and 81273376). Introduction Free fatty acids (FFAs) are important metabolic fuels and those that are polyunsaturated are essential components of t

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