• While oxysterols were most extensively studied for

  2021-06-15

  

  While oxysterols were most extensively studied for its potent ability to mediate feedback regulation of cholesterol biosynthesis, some early investigations showed that the enzymes involved in its syntheses were highly upregulated in macrophages and dendritic cells—an indication of possible roles in

• How does APC C recognize its substrates and

  2021-06-15

  

  How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac

• HOIP s ability to build linear Ub

  2021-06-15

  

  HOIP's ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [40

• br Authors contribution br Disclosure statement br

  2021-06-15

  

  Authors contribution Disclosure statement Acknowledgements This study has received funding from the Italian Ministry of University and Research (PRIN 2015, grant number 2015373Z39_008) and from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115797 (INNODIA)

• During the past three decades platinum based

  2021-06-15

  

  During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot

• Several studies have described the role of NP

  2021-06-15

  

  Several studies have described the role of NP in vRNP nuclear export. For example, leptomycin B (LMB), an inhibitor of the CRM1 nuclear export signal (NES) binding domain (Kudo et al., 1999), inhibits nuclear export of vRNP and NP, but not NEP or M1, in virally infected or transfected AI-10-49 (Elt

• The objective of the present

  2021-06-15

  

  The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in Oltipraz receptor regions belonging to the reward pathway using a

• br Results On the th day the horizontal Fig

  2021-06-15

  

  Results On the 8th day, the horizontal (Fig. 1) and vertical locomotor activity (Fig. 2) and the dorsal (Fig. 3) and NHS-12-Biotin australia striatal dopamine release (Fig. 4) increased significantly in nicotine-treated rats, compared with the saline-treated rats. Tukey post-hoc test revealed the

• The immune control of CMV replication in vivo is

  2021-06-11

  

  The immune control of CMV replication in vivo is primarily driven by the T-cell-mediated response, a characteristic that has been proposed as a tool to individualize and therefore to optimize antiviral treatment [6], [7], and it has been associated with spontaneous clearance of CMV viraemia in patie

• br Results br Discussion br

  2021-06-11

  

  Results Discussion Conclusions Acknowledgments The basic studies were funded in part by a grant of the Clinical Research, Endocrinology and Metabolism Merck Research Laboratories, Medical School Grant Committee for Ezetimibe, Rahway, NJ, USA. Introduction Elevated cholesterol, partic

• Early studies from the mollusk Aplysia reported

  2021-06-11

  

  Early studies from the mollusk, Aplysia, reported the presence of a unique class of thapsigargin receptors in neurons, the acetylcholine-gated chloride channels (ACCs) (Kehoe and McIntosh, 1998). Later, studies identified these receptors in the model nematode Caenorhabditis elegans (Putrenko et al.

• In the literature we can

  2021-06-11

  

  In the literature, we can find two different modes of action for estrogens: Firstly there is the commonly accepted genomic pathway. Estrogens pass the cell membrane due to their lipophilic character via diffusion and bind to estrogen receptors (ERs) in the cytoplasm. After binding a dimerization of

• EphB promotes tumor growth by stimulating

  2021-06-11

  

  EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of Zoniporide dihydrochloride and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stain

• Enolase as a plasminogen receptor and activator localized on

  2021-06-11

  

  Enolase, as a plasminogen receptor and activator localized on the surface of several helminths, can interact with the host fibrinolytic system (Yang et al., 2010, Du et al., 2009, de la Torre-Escudero et al., 2010). The enzyme is also one of excretory/secretory (ES) products in some helminths, such

• br Results and Discussion br Experimental Procedures br Ackn

  2021-06-11

  

  Results and Discussion Experimental Procedures Acknowledgments The ubiquitin–proteasome system (UPS) is important for biological processes such as protein degradation and protein function regulation. In general, poly-ubiquitinated proteins are degraded by proteasomes, and some proteins ac

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