• A set of small molecule

  2021-02-02

  

  A set of small molecule LigI inhibitors were identified through an in silico structure-based screen, using the atomic resolution structure of LigI complexed with nicked DNA [[18], [26]]. This screen yielded inhibitors that were selective for LigI (L82), inhibited both LigI and LigIII (L67) and inhib

• To better understand Wolbachia s dependence on these enzymes

  2021-02-02

  

  To better understand Wolbachia’s dependence on these enzymes, RNAi experiments targeting these transcripts will be required to examine the consequences of their down-regulation on Wolbachia in the different tissues of the parasite. Initial studies have shown that decreases in Bm-cpl-3 and Bm-cpl-6 t

• Acidic substituents showed moderate biochemical activity but

  2021-02-02

  

  Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic what is doxycycline hyclate were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of th

• br Materials and methods br

  2021-02-02

  

  Materials and methods Results and discussion Conclusions Given that the activity of anti-plant virus compounds is related to host tobacco, virus, and compounds, we determined the effect of anti-CMV compound NNM on defense enzyme activity and chlorophyll index in tobacco, and we used RIB as

• In a study performed simultaneously by another group EWS

  2021-02-02

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived MK-3207 HCl resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sarcoma an

• Introduction Fish commonly employ pheromones to regulate a v

  2021-02-02

  

  Introduction Fish commonly employ pheromones to regulate a variety of functions including reproductive communication [1]. Reproductive pheromones induce both primer effects, such as changes in the endocrine or physiological state of conspecifics, and releaser effects such as rapid behavioral respon

• br Materials and methods br Results Overexpression of

  2021-02-02

  

  Materials and methods Results Overexpression of KLF2 increased the cell viability and reduced the LDH leakage rate and O2•− and ONOO− generation in H/R HUVEC model. To evaluate the effect of KLF2 on H/R HUVEC injury, KLF2 was overexpressed in HUVECs. Cell viability and extracellular LDH level

• Moreover Hypericum perforatum L was also included

  2021-02-02

  

  Moreover, Hypericum perforatum L. was also included in the initial screening, showing only a weak percentage of inhibition on both enzymes. In fact, it was not selected among the most active plants. The phytochemical profiles of these three Hypericum species were already reported to be significantly

• In the phase I AURA trial patients with

  2021-02-02

  

  In the phase I AURA trial, patients with EGFR activating mutations and centrally confirmed tumor and/or plasma genotyping (BEAMing) T790M result were enrolled. Among 216 patients with both plasma and tissue genotyping results, the concordance rate was 82% for nkh 19 deletions, 86% for L858R and 70%

• Does a universal mechanism for TLS exist Our previous studie

  2021-02-02

  

  Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA

• br Acknowledgement This study was supported by Vetenskapsr d

  2021-02-01

  

  Acknowledgement This study was supported by Vetenskapsrådet, Sweden (Grant 2017-02918). Introduction Soybean is a major source of protein and oil used for food and feed, as well as for the production of industrial products like lubricants and hydraulic fluids (Choudhary and Tran, 2011; Hsien,

• Finally unilateral microinjection of CP Astressin B

  2021-02-01

  

  Finally, unilateral microinjection of CP-376395, Astressin 2B, CP-376395 + CRF or ASTR 2B + CRF into the BLA (Fig. 3A) or CeA (Fig. 3B) did not significantly alter spontaneous motor activity in the open field test (F4,24 = 0.148, P > 0.05; F4,29 = 0.290, P > 0.05 in the BLA and CeA, respectively, AN

• In order to validate the ATP competitive mode

  2021-02-01

  

  In order to validate the ATP competitive mode of inhibition, compound 12 was selected as a representative inhibitor of this series, and the IC50 values were determined at eight different concentrations of compound 12 ranging from 0.001 to 100 μM, and repeated four times using different ATP concentra

• In countries such as China where there is a high

  2021-02-01

  

  In countries such as China where there is a high commercial production of rice, the use of rice husk ash (RHA) as an alternative cementing material can become a great asset for environmental rehabilitation and address the difficult disposal issues associated with this agricultural waste [23]. RHA po

• br Methods br Results br Discussion

  2021-02-01

  

  Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide Endoxifen dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase and NO

14418 records 696/962 page Previous Next First page 上5页 696697698699700 下5页 Last page