• br Ubiquitin ligases Ubiquitin ligases

  2020-12-22

  

  Ubiquitin ligases Ubiquitin ligases are categorized into different THZ1 based on their specific structural configuration and the composition of subunits—HECT (homologous to E6-AP1 (E6-associated protein 1) carboxy-terminus)-type, RING (really interesting new gene)-finger-type, U-box-type, or RIN

• The ubiquitin proteasome system Ub P is the main

  2020-12-21

  

  The ubiquitin–proteasome system (Ub–P) is the main cellular machinery for protein turnover in eukaryotic cells (Glickman and Ciechanover, 2002). Degradation by Ub–P involves two steps. Target proteins are selectively, specifically, and covalently attached to ubiquitin (Ub) chains, followed by Ub-tag

• br Expression and Purification of Atg

  2020-12-21

  

  Expression and Purification of Atg4 and Atg8 Proteins for In Vitro Assays Measurement of Atg4 Activity In Vitro and Ex Vivo Kinetics Analysis of Atg4 Enzymes Summary Atg4 proteases play a crucial role in preparing Atg8 for conjugation to lipid membranes and for the deconjugation of Atg8

• br Materials and methods br Results and discussion

  2020-12-21

  

  Materials and methods Results and discussion In the present work, we have applied two methodologies, CoMFA and CoMSIA to build 3D-QSAR models. There is no crystal structure available; therefore, an indirect method i.e., a ligand-based approach is the method of choice. The highly active molecul

• br Conclusions br Acknowledgments This work

  2020-12-21

  

  Conclusions Acknowledgments This work was supported by a grant from NIH from the National Institutes on Arthritis and Musculoskeletal and Skin Diseases [AR056092]. Introduction Prior exposure to stressors has been consistently associated with the manifestation and/or exacerbation of psychi

• In frame exon skipping of

  2020-12-21

  

  In frame exon 41 skipping of COL6A3 has been suspected to be responsible for isolated dystonia in several human kindreds without muscular defects [94]. In order to validate their hypothesis, the authors used zebrafish to selectively knock down several exons in col6a3 and found a negative impact on m

• br Introduction The cys loop ligand gated

  2020-12-21

  

  Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri

• EP receptors belong to the

  2020-12-18

  

  EP1–4 receptors belong to the family of G protein-coupled receptor (GPCR). Trafficking events such as externalization, internalization, recycling and degradation dynamically regulate GPCR cell surface density. A fast-rate of internalization and degradation reduces GPCR surface density to desensitize

• The synthesis of the required substrates is shown in

  2020-12-18

  

  The synthesis of the required substrates is shown in (see for experimental details). Treatment of heterocycle with Cabazitaxel under basic conditions afforded a mixture of the mono-substituted product (22%) and the di-substituted compound (38%) which were separated by column chromatography. Compound

• A growing body of data indicates

  2020-12-18

  

  A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream Telotristat molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apoptosis, whereas a reduction in the concentra

• It is particularly notable that CYP D

  2020-12-18

  

  It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 ddhC in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and between individu

• Herbal products may alter the metabolism of

  2020-12-18

  

  Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 L-Phenylephrine (CYP). These can bring about an alteration of the pharmacokinetics and pharmacologica

• The enantiomeric ratio ER of chiral compounds accumulated in

  2020-12-18

  

  The enantiomeric ratio (ER) of chiral compounds accumulated in organisms has been found to be different among species (Borga and Bidleman, 2005, Harner et al., 1999, Warner et al., 2005, Wiberg et al., 2000), indicating enantioselective accumulation of chiral compounds are species-specific. The ER o

• We not only found that the ISR leads to

  2020-12-18

  

  We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is

• In an effort to discover additional

  2020-12-18

  

  In an effort to discover additional GPCRs directing the migratory events of responding B cells, we identified Epstein-Barr virus (EBV)-induced gene 2 (EBI2) as a promising candidate. The gene encoding EBI2 (Ebi2, also known as Gpr183) was originally identified together with Ebi1 (Ccr7) as the most h

14371 records 718/959 page Previous Next First page 上5页 716717718719720 下5页 Last page