• br Conflict of interest br Acknowledgments This

  2020-07-31

  

  Conflict of interest Acknowledgments This work was supported by grants from the Ministry of Science (N N302 113337). The Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University is a beneficiary of the European Union structural grant “Molecular Biotechnology for Hea

• Medaka Oryzias latipes is used as

  2020-07-31

  

  Medaka (Oryzias latipes) is used as a useful model in radiation biology [10], [11]. RIC1 strain was isolated as a radiation-sensitive mutant strain of Medaka via N-ethyl-N-nitrosourea ENU-mutagenesis screening [12]. Previously, we established four RIC1 cell lines from each single embryo and reported

• COMT enzyme activity and protein expression have

  2020-07-31

  

  COMT enzyme activity and protein expression have been shown to increase with age across the human lifespan (Tunbridge et al., 2007). In addition, healthy individuals carrying the COMT Val/Val genotype have higher grey matter density in early adulthood, but this difference disappears as age increase

• Our results also suggest a relationship between the COMT

  2020-07-31

  

  Our results also suggest a relationship between the COMT rs4680 polymorphism and psychiatric symptomatology in epilepsy. As a group, Val carriers had higher scores on the Schizophrenia, Antisocial Features, and Alcohol Problems scales of the PAI than those without a Val allele. The Val allele has pr

• In this present study we aimed to determine

  2020-07-31

  

  In this present study, we aimed to determine the mechanisms of which E2 and GEN regulate COMT gene expression, via epigenetic modifications at the 5′ regulatory region of COMT in MCF-7 cells. Sulforaphane (SFN) is an inducer of phase II protective enzymes including glutathione-S-transferases and qui

• The CD cysteine protease of S mansoni Sm also

  2020-07-30

  

  The CD13 cysteine protease of S. mansoni (Sm32, also known as SmAE or schistosome legumain) is an asparaginyl endopeptidase (AE) that cleaves C-terminal to asparaginyl (Asn) residues (Dalton et al., 2009). This protein has been characterized, cloned and sequenced (Klinkert et al., 1989; Davis et al.

• The concept of GPCRs and EGFRs

  2020-07-30

  

  The concept of GPCRs and EGFRs existing as heteromers is consistent with previous studies. Co-immunoprecipitation studies have shown that agonist stimulation (both AngII and EGF) promotes a multi-protein complex containing the AT1R and EGFR, however these endpoint assays were not in live cells or in

• As EBI is highly important for generation of an efficient

  2020-07-30

  

  As EBI2 is highly important for generation of an efficient T cell-dependent humoral immune response [[5], [6], [7]] it may be that aberrant expression or other dysregulation of this receptor contributes in B cell pathologies. In line with this, EBI2 expression is down-regulated in diffuse large B-ce

• There is plenty of evidence

  2020-07-30

  

  There is plenty of evidence that rs1611115 effects phenotypes related to catecholaminergic activity. With respect to drug addiction carriers of the TT genotype show increased severity of heroin use (Xie et al., 2013) and poorer cocaine treatment outcomes (Kosten et al., 2013). Moreover, disulfiram,

• The focus of this work was to determine

  2020-07-30

  

  The focus of this work was to determine which E. coli genes contribute to survival upon exposure to CAA and SO. We first analyzed the expression of certain stress response genes upon exposure to each agent, using the established Transcriptional Effect Level Index (TELI) assay [34]. The main advantag

• The molecular docking data supported

  2020-07-30

  

  The molecular docking data supported the potential interaction of lapachol and the synthetic naphthoquinonolyl compounds with the PfDHODH enzyme as the putative mechanism of action and the inhibition of parasite growth in vitro. In general, compounds fit well into the binding pocket of PfDHODH, the

• Dehydrogenation by a KSTD is also a crucial step

  2020-07-30

  

  — 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during Carprofen degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic steroid degra

• Less stringent mining of the literature using the term DDR

  2020-07-30

  

  Less stringent mining of the literature using the term ‘DDR1’ in potent web search tools such as Thomson Integrity [83] yields an impressive number of results for both scientific publications and patents (respectively 1219 and 267) in multiple indications (Fig. 4B). Unfortunately, the majority of th

• DAPK is involved in the p

  2020-07-30

  

  DAPK-1 is involved in the p53 dependent apoptotic pathway and it is a mediator of γ-interferon induced apoptosis. DAPK-1 is also involved in other death signaling pathways (tumor necrosis factor-α, CD95 and transforming growth factor-β) and it blocks tumor metastasis in vivo. The loss of DAPK mRNA P

• br The Structure and Regulatory Machinery of

  2020-07-30

  

  The Structure and Regulatory Machinery of Atg4 Atg4 proteases range from 393 to 474 o6 methylguanine methyltransferase in size and possess several structural features of cysteine proteases. The crystal structure of Atg4A (PDB ID: 2P82) has been resolved (Fig. 2A). Atg4A shares a similar catalyti

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