• The possibility of harm with DPP inhibitors

  2020-02-05

  

  The possibility of harm with DPP-4 inhibitors in patients with clinically overt heart failure has been recently highlighted by the results of the VIVIDD (Vildagliptin in Ventricular Dysfunction Diabetes) trial (68), the only trial to date that has been designed to evaluate the effects of a DPP-4 inh

• The lungs dissected from week mice were cut into

  2020-02-05

  

  The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco\'s modified Eagle\'s medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37 °

• br Methods br Results br Discussion Skin biopsy and

  2020-02-04

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific dna methyltransferase organs (Donadio et al., 2005, Donadio et al., 2012a, Dona

• As previously stated the most

  2020-02-04

  

  As previously stated, the most unexpected finding from this series of compounds was the identification of a dimethyl isoxazole side chain that gave dramatically improved binding over the parent compounds. Holding this piece of the molecule constant, a series of analogs were made to further understan

• Levodopa Introduction The inflammation process involves sequ

  2020-02-04

  

  Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases Levodopa were responsible for activation of the production of prostaglandins (PG1s) and ot

• In the particular case of metals several authors showed that

  2020-02-04

  

  In the particular case of metals, several authors showed that AChE inhibition is somewhat contradictory and even questionable (Frasco et al., 2005, Nunes et al., 2005, Sáenz et al., 2010). Uranium is a particular metal, and one that has been shown to complex with several biologically important prote

• Water inorganic salts sugars lipids nucleic acids and

  2020-02-04

  

  Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and

• Several reasons may explain that other studies using

  2020-02-04

  

  Several reasons may explain that other studies using PDE-5-Is yielded negative or contradictory results [30], [31], [32]. Lee [30] applied 50mg sildenafil to seven patients with liver cirrhosis. NO and cGMP in the hepatic GSK180 significantly increased, hepatic and pulmonary resistance decreased, a

• Although we observed increases in AR

  2020-02-04

  

  Although we observed increases in α1-AR mediated cAMP production separately in the nucleus and cytoplasm, compartment specificity was observed for PKA activation. GPCRs and their effector proteins are commonly found in multiprotein signalosomes with A-kinase anchoring proteins (AKAPs) serving as sca

• Among the different factors that modulate Schwann

  2020-02-04

  

  Among the different factors that modulate Schwann cell biology, several studies pointed out the role played by neuroactive steroids, in particular progesterone (P4) and its derivatives dihydroprogesterone (DHP) and allopregnanolone (ALLO). Schwann scopolamine hydrobromide are steroidogenic, possess

• br Introduction Breast cancer is the most

  2020-02-04

  

  Introduction Breast cancer is the most common malignant tumor in women and the second leading cause of female death [1]. In recent years, with the improvement of early detection and the emergence of new treatment methods, the mortality rate of breast cancer has been greatly reduced. However, the

• ekb br Transparency document br Introduction The cyclic nucl

  2020-02-04

  

  Transparency document Introduction The cyclic nucleotide adenosine 3′,5′-cyclic monophosphate (cAMP) exerts both an endothelium-dependent and an endothelium independent vasorelaxant action in rat ekb [1]. cAMP direct, endothelium-independent vasorelaxant effects have been attributed to severa

• Another milestone in the field is the de novo

  2020-02-04

  

  Another milestone in the field is the de novo discovery of EPAC2 and EPAC1 specific inhibitors through fluorescence-based HTS assays. Due to the excellent EPAC/PKA selectivity of Minocycline HCl , it has been widely applied as a useful chemical probe to discriminate EPAC related signaling pathways

• plerixafor The compounds listed in Table Table Table Table T

  2020-02-04

  

  The compounds listed in Table 1, Table 2, Table 3, Table 4, Table 5 were biologically evaluated for their inhibition of the specific binding of a radiolabeled ligand [3H]PGE2 to membrane fractions prepared from cells stably expressing each mouse prostanoid receptor. The EP1 antagonist activity of th

• 7915 DNA replication checkpoint kinases in both yeast and hu

  2020-02-04

  

  DNA replication checkpoint kinases in both yeast and human 7915 upregulate dNTP levels under replication stress to mediate their essential function at replication forks (Yeeles et al., 2013). It is possible that upregulation of dNTP levels under replication stress helps fork restart once replication

14409 records 879/961 page Previous Next First page 上5页 876877878879880 下5页 Last page