• br Acknowledgements The authors are

  2020-01-17

  

  Acknowledgements The authors are supported by National Institutes of Health grants (CA162804, CA92584, and CA13499 to DJC and CA166677 to BPPC) and Cancer Prevention and Research Institute of Texas (RP110465 to DJC). The cellular response to DNA double-strand break (DSB) formation is an essent

• In attempts to further purify His Artemis numerous matrices

  2020-01-17

  

  In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and Cy3 NHS ester (non-sulfonated) receptor interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatograp

• Binding affinity was measured by a

  2020-01-16

  

  Binding affinity was measured by a scintillation proximity binding assay using [H]4-OHT (ERRγ) or [H]estradiol (ERα/β) as radioligand. In all cases, the ERβ affinity was not significantly different from ERα. Compounds were compared to , which showed high affinity for both receptors and moderate (six

• br Conclusions br Declaration of interest br Acknowledgement

  2020-01-16

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• The aim of this study was to

  2020-01-16

  

  The aim of this study was to discover and characterize a novel thermostable gluten-specific prolyl endopeptidase suitable for use during the mashing step of beer production. Subsequently to express the recombinant enzyme in E.coli and to demonstrate degradation of immunogenic gluten derived peptides

• br Results br Discussion The origin

  2020-01-16

  

  Results Discussion The origin and fate of Tfh cells has been intensely studied since their first description 14 years ago (Breitfeld et al., 2000, Schaerli et al., 2000). Although mice engineered to report BCL6 (Kitano et al., 2011, Liu et al., 2012) and interleukin-21 (IL-21) (Lüthje et al.,

• HOIP s ability to build linear Ub

  2020-01-16

  

  HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [4

• The findings of Qiu et al represent the first instance

  2020-01-16

  

  The findings of Qiu et al. (2016) represent the first instance of a Ub-specific mono-ADP-ribosyltransferase, as well as the first documentation of E1/E2 independent ubiquitination. Post-translational modification of Ub certainly adds layers of complexity to our understanding of the Ub signal and sho

• HAT Inhibitor II synthesis Elevation of plasma glucocorticoi

  2020-01-16

  

  Elevation of plasma glucocorticoids as well as a sympathetic activation are highly adaptive mechanisms allowing the individual to cope in various situations [39]. Novelty-induced increase in locomotor activity, characterizing the bold fish herein, accompanied by elevated glucocorticoids is a well-es

• csf1r br Materials and methods br Statistical

  2020-01-16

  

  Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein csf1r data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparametric data of DNMTs pr

• br Anti inflammatory effects of MTX

  2020-01-16

  

  Anti-inflammatory effects of MTX In addition to cytotoxic and cytostatic effects, the anti-inflammatory activity of MTX was also described by several studies. Inhibition of ATIC by MTX has been found to result in the accumulation of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranosyl 5′-monophosph

• In this review focusing on biocatalyst formate dehydrogenase

  2020-01-16

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic btz calculator oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and

• To determine the time course

  2020-01-16

  

  To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour UNC669 receptor were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggesting t

• Many authors have described the

  2020-01-16

  

  Many authors have described the existence of correlation between viability and moisture content and therefore, water availability. Sabuquillo et al. (2010) demonstrated that only Penicillium oxalicum conidial formulations whose initial moisture contents ranged between 5 and 14% retained their viabil

• Conventional configurations for alkanolamine and

  2020-01-16

  

  Conventional configurations for alkanolamine and E-64-c gas are not suitable to represent the chemical reaction between acid gas and alkanolamines. Nevertheless, Dowell et al. [17] have successfully represented the phase behaviour of CO2-water-MEA systems by using SAFT-VR [18] without any considera

14409 records 888/961 page Previous Next First page 上5页 886887888889890 下5页 Last page